Abstract Although second-generation therapies like abiraterone (ABI) and enzalutamide (ENZ) benefit patients with castration-resistant prostate cancer (CRPC), drug resistance frequently occurs, eventually resulting in therapy failure.In this study, we used two libraries, FDA-approved drug library and CRISP/Cas9 knockout (GeCKO) library to screen Co
This study investigated HIV and syphilis incidence among men who have sex with men (MSM) in Beijing, China.An open cohort was established from September 2009 to April 2012.Participants were followed up with every three to four months after recruitment and for thirty-one months in total.Chi-square tests were used to compare demographic and behaviora
Abstract Exposure to biodiverse aerobiomes supports human health, but it is unclear which ecological factors influence exposure.Few studies have investigated near-surface green space aerobiome dynamics, and no studies have reported aerobiome vertical stratification in Shelving Unit different urban green spaces.We used columnar sampling and next gen
The assessment of anthropogenic impacts on the marine environment is challenged by the accessibility, accuracy and validity of biogeographical information.Offshore wind farm projects require large-scale ecological surveys before, during and after construction, in order to assess potential effects on the distribution and abundance of protected speci
Machine Reading Comprehension (MRC) is a challenging task in Natural Language Processing (NLP), crucial for automated customer support, enabling chatbots and virtual assistants to accurately understand and respond to queries.It also enhances question-answering systems, benefiting educational tools, search engines, and help desks.The introduction of